Cope with changing weather patterns and enjoy beautiful vistas, sunsets, moonlight, and more.See every detail in stunning 3D with fully controllable park cameras.Grab a front seat for the ride of your life with the jaw-dropping Coaster Cam.Watch guest reactions to your ultimate theme park! Build your own water slide or create your own safari with real animals. RCT3 Platinum combines the roller coaster theme park fun of the Roller Coaster Tycoon 3 with included expansion packs Soaked! and Wild! Now enjoy more options than ever. Activation of the reporter gene provides a quantifiable measurement of the degree of interaction between the target receptor and the protease-tagged arrestin partner.Rollercoaster Tycoon 3 Platinum combines the excitement of rollercoasters with the fun of great strategy sim. The blue to green fluorescence ratio obtained directly correlates to receptor modulation by agonists or antagonists. There, the transcription factor directly regulates transcription of a beta-lactamase reporter construct, which is measured upon addition of the live-cell substrate (Figure 2).
This transcription factor immediately enters the nucleus, thus bypassing additional signaling intermediates. The protease-tagged arrestin cleaves a protease site fused to the C-terminus of the GPCR, releasing a non-native transcription factor. The Tango GPCR Assay System (Figure 1) is a proprietary platform based upon ligand binding to a specific G protein-coupled receptor (GPCR) that triggers desensitization, a process mediated by the recruitment of protease-tagged arrestin proteins to the activated receptor.
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